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As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

  • The submission has not been previously published, nor is it before another journal for consideration (or an explanation has been provided in Comments to the Editor).
  • The submission file is in OpenOffice, Microsoft Word, or RTF document file format.
  • Where available, URLs for the references have been provided.
  • The text is single-spaced; uses a 12-point font; employs italics, rather than underlining (except with URL addresses); and all illustrations, figures, and tables are placed within the text at the appropriate points, rather than at the end.
  • The text adheres to the stylistic and bibliographic requirements outlined in the Author Guidelines.

Guidelines for Authors for Submitting a Manuscript


The manuscript should be unique and has not been published elsewhere. All authors should have read and approved the authorship responsibility and ethics principles presented on our website. All authors should provide a competing interest statement. One author should be designated as the corresponding author, and the contact details, including the email address, should be supplied. All abstracts should be structured. The following types of manuscripts can be submitted: original article, review article, editorial, hypothesis, letter, and case reports (preferably with a comprehensive literature review).


Requirements for Different Types of Articles


Original articles: Should contain a structured abstract, 3 to 5 keywords, introduction, methods, results, discussion, conclusions, ethical declaration, funding, acknowledgment, and references. There were no restrictions on supporting documents. Randomized controlled trials (RCTs) should be registered at any RCT registry approved by the World Health Organization.


Case reports (preferably with a comprehensive literature review): Should contain a structured abstract, 3 to 5 keywords, introduction, case presentation, discussion, conclusions, ethical declaration, funding, acknowledgment, and references. If an individual case is described, his or her consent should be obtained. The journal retains the right to ask for the original signed informed consent form. 


Review articles: Review articles, systematic reviews, and meta-analyses are most welcome. The protocol of the systematic reviews and meta-analyses should adhere to the PRISMA guidelines.


Hypothesis: The main body of this manuscript consists of an introduction, hypothesis, evaluation of hypotheses, and conclusions. The structured abstract of this article type should consist of a background, hypothesis, and conclusions.


Editorials and letters: Letters and editorials should preferably be less than 2500 words. Letters discussing articles published in the journal should be submitted within 6 months after the publication of the main article. Editorials and letters will undergo peer review. These articles have no abstracts.


Manuscripts should be prepared based on the following segments:


A cover letter, which should contain the rationale for performing the research and should state that you will not submit your article to another journal until the review process is completed. The authors should also indicate if they have published or submitted any related papers from the same study, to prevent salami plagiarism.


The title page should include the title of the study, the name of the authors (with an email address for each author), and their affiliations on the first page of the manuscript. The complete mailing address, telephone number, and email address of the corresponding author should be mentioned.


Abstract: The abstract should be less than 350 words, structured, concise, and comprehensible to readers. Keywords should be provided for indexing purposes; 3 to 5 keywords should be selected from Medical Subject Headings (MeSH).


The Introduction should cover a short background of former studies and should indicate potential gaps in the literature, and should specify the aim of the study.


The Methods should indicate the stepwise approach taken to acquire the data and should include a description of the statistical analysis. It should mention the inclusion and exclusion criteria and should preferably be presented in chronological order. For reports of RCTs, the authors should refer to the CONSORT statement. Reporting guidelines can help authors present high-quality studies and deliver all the required information and evidence. The EQUATOR Network website can assist authors in using these guidelines.


The Results should be presented in chronological order in the text. Tables and figures must be cited in the order in which they appear in the text, should be presented with a separate footnote or legend, and should define all abbreviations. Tables should be simple and include titles, descriptions, and footnotes. Ensure that all figures and tables have been cited in the text. Tables should not duplicate information given in the text. Figures should be provided only if they present additional information. High-resolution figures should be presented in TIFF format, with a dpi of 600. If you have reused or adapted figures, tables, or sections of text from papers published elsewhere, please obtain permission from the copyright owner to re-use those elements.


The Discussion should provide a discourse on the outcomes of the research in the light of other publications in the literature, in the format of arguments and counterarguments. The limitations and strengths of the study and the implications of the findings for future studies or for clinical practice should be presented.


The Conclusions should present the final outcome of the study and should present the implications or recommendations based on the study findings. Of note, conclusions should not overstate and/or overreach the results.


The Ethical declaration should present the ethical approval of the study and any conflicts of interest of the authors that should be reported.


The Funding resources and Acknowledgments should be clearly declared in all submissions.  


The References should be presented in numerical order, according to the order of citations in the text. The journal follows the “Vancouver” style, as outlined in PubMed. For different types of references, please refer to “the NLM style-guide for authors, editors, and publishers”.


All references cited in the reference list should be cited in the text.


Article Processing Fee: The Journal receives no government, educational, charitable, or any other kind of funding. We do not accept advertisements. Therefore, we publish the journal based on the article processing fees obtained from the authors. Submission of a manuscript and peer-review processes are free of charge. An article-processing fee applies only to accepted manuscripts. If a paper is accepted for publication, the authors need to pay a publication processing fee equal to 2400 EURO prior to proof. Article Processing Fee covers the cost of open access manuscripts, journal production, web hosting, CMS, database, online repository, archiving, XML conversion, reference formatting, unlimited number of color figures, and free extensive English editing.