Serum Vitamin A Level in Patients with Chalazion

Mohammad Malekahmadi, Fereydoun Farrahi, Afshin Tajdini


Chalazion is a chronic and localized lipogranulomataus inflammation of the sebaceous gland of lids that are meibomian and Zeis glands. Chalazion occurs often secondary to blockage of the sebaceous gland ducts.  In few studies Vitamin A deficiency is reported as a risk factor for chalazion.

This was a prospective case-control study on 107 subjects as 52 patients with chalazion, and 55 control subjects conducted at ophthalmology clinics of Imam Khomeini hospital, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran, between September 2014 and February 2015. All subjects divided to 3 subgroups by age: 7-12 years old, 13-19 years old, and >19 years old. Also all cases, were divided to four subgroups of single, multiple, primary and recurrent chalazion. The blood samples were collected for case and control groups. Serum was tested for levels of Vitamin A, using high-performance liquid chromatography (HPLC) system.

Average Serum Vitamin A levels in patient with chalazion at age range 7-12 and 13-19 years old were significantly lower than their control subjects. Serum Vitamin A level of patients with recurrent multiple chalazion was lower than patients with primary multiple chalazion, (P-value=0.026) and also was lower than patients with recurrent single chalazion (P-value=0.029).

Chalazion could be one of the ocular presentations of vitamin A deficiency in children and this can be helpful in early diagnosis and treatment of Vitamin A deficiency to prevent further complications like xerosis and nyctalopia.

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