Relationship of Body Mass Index and Blood Pressure with Corneal Biomechanical Parameters in Healthy Subjects

Mohamad-Reza Sedaghat, Farshad Askarizadeh, Mohsen Nematy, Foroozan Narooie-Noori, Javad Heravian, Tahereh Rakhshandadi, Sattar Rajabi

Abstract


The aim of this study was to assess the possible relationship of body mass index (BMI) and blood pressure (BP) with corneal biomechanical parameters in healthy subjects.This study included 88 eyes of 88 healthy subjects aged 20-40 years. After a thorough medical history and comprehensive ophthalmic examination, the body height and weight were measured; then, the BMI was calculated. A digital sphygmomanometer was used to measure systolic (SBP) and diastolic blood pressure (DBP). All cases were evaluated with Pentacam (Oculus) in order to rule out corneal ectasia; then, the corneal biomechanical parameters of all individuals were measured using the Scheimpflug-based Corvis ST (Oculus Optikger¨ate GmbH, Germany). If the measurements of hematological-biochemical parameters were within normal range, the results of the Corvis ST, BMI, and BP were included in the analysis carried out with SPSS. software.The mean (±SD) BMI, SBP, DBP, IOP, CCT, deformation amplitude, radius, and peak distance was 27.24±4.80 kg/m2, 116.47±11.21 mmHg, 80.51±5.68 mmHg, 15.10±1.70 mmHg, 533.10±30.97 ϻm, 1.03±0.11 mm, 7.51±0.86 mm, and 5.03±0.30 mm, respectively. Based on the world health organization’s categorization for BMI, the results showed no significant difference in IOP, CCT, peak distance, radius, and deformation amplitude between different BMI subcategories (all p >0.05). The results of the Corvis ST showed that corneal biomechanical parameters had no significant correlation with BMI, SBP, and DBP in three subgroups of BMI and all participants (all p >0.05). There was a positive correlation between CCT and IOP (p <0.001, r= 0.504) in all participants. CCT and IOP had no correlation with BMI, SBP, and DBP (all p>0.05). This study showed that BMI and BP had no correlation with corneal biomechanical parameters in healthy subjects using the Corvis ST. Our results can be used in clinical practice.




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