Sodium Fluorescein Staining of the Cornea for the Diagnosis of Dry Eye: A Comparison of Three Eye Solutions

Ming CHEN; Maile MIKI; Szuyuan LIN; So YUNG CHOI

Sodium Fluorescein Staining of the Cornea for the Diagnosis of Dry Eye: A Comparison of Three Eye Solutions

Medical hypothesis discovery and innovation in ophthalmology, Vol. 6 No. 4 (2017), 1 December 2017 , Page 105-109
Published 31 December 2017

Abstract

The purpose of this study was to identify which of the eye solutions is best for sodium fluorescein staining of the cornea to diagnose dry eye disease. The study included 173 eyes with suspected or known dry eye disease. The eyes were stained sequentially with sodium fluorescein and each of the following four conditions: balanced salt solution (BSS); BSS and cyclosporine 0.05% emulsion; BSS and lipids containing omega-3; and BSS, cyclosporine 0.05% emulsion, and lipids containing omega-3. Our results showed that compared to BSS alone, artificial tears with cyclosporine 0.05% emulsion and lipids containing omega-3 remain in the cornea for longer periods, thus allowing the clinician to evaluate tear break-up time and visualize corneal punctate erosions.

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References

International Dry Eye Workshop. DEWS Report. Ocular Surface, 2007.

International Dry Eye Workshop. DEWS II: Redefining Dry Eye. Ocular Surface, 2017.

Schacter S. Schacter Factor: Evaporative dry eye vs. aqueous tear deficiency. Optometry Times, 2015.

National Eye Institute. Facts about Dry Eye. National Eye Institute, 2017.

Lemp M, Geerling G. Distinguishing Evaporative from Aqueous Deficient Dry Eye. Cataract Refract Surg Today. 2011;9(2):140-59.

Boyd K. Causes of Dry Eye. USA: American Academy of Ophthalmology; 2017.

Phadatare SP, Momin M, Nighojkar P, Askarkar S, Singh KK. A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges. Adv Pharmac. 2015;2015:1-12. doi: 10.1155/2015/704946

Uchino M, Schaumberg DA. Dry Eye Disease: Impact on Quality of Life and Vision. Curr Ophthalmol Rep. 2013;1(2):51-7. doi: 10.1007/s40135-013-0009-1 pmid: 23710423

Ayaki M, Kawashima M, Negishi K, Tsubota K. High prevalence of sleep and mood disorders in dry eye patients: survey of 1,000 eye clinic visitors. Neuropsychiatr Dis Treat. 2015;11:889-94. doi: 10.2147/NDT.S81515 pmid: 25848288

Javadi MA, Feizi S. Dry eye syndrome. J Ophthalmic Vis Res. 2011;6(3):192-8. pmid: 22454735

Ames P, Galor A. Cyclosporine ophthalmic emulsions for the treatment of dry eye: a review of the clinical evidence. Clin Investig (Lond). 2015;5(3):267-85. doi: 10.4155/cli.14.135 pmid: 25960865

Gore A, Attar M, Pujara C, Neervannan S. Ocular emulsions and dry eye: a case study of a non-biological complex drug product delivered to a complex organ to treat a complex disease. Generic Biosimilar Initiative J. 2017;6(1):13-23. doi: 10.5639/gabij.2017.0601.004

International Dry Eye Workshop. The definition and classification of dry eye disease: report of the definition and Classification Subcommittee of the international Dry Eye Workshop, 2007.

Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, et al. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009;50(7):3203-9. doi: 10.1167/iovs.08-2476 pmid: 19255163

Tear Science, a streamlined method for evaluating the Meibomian glands: Tear Science Web site; 2017 [cited 2017 December 5]. Available from: https://tearscience.com.

Oculus Inc. The OCULUS keratography 5M: Oculus, Inc; 2017 [cited 2017 December 5]. Available from: https://www.oculus.de/us/products/topography/keratography-5m.

Finis D, Pischel N, Schrader S, Geerling G. Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction. Cornea. 2013;32(12):1549-53. doi: 10.1097/ICO.0b013e3182a7f3e1 pmid: 24097185

Torkildsen G, Brujic M, Cooper MS, Karpecki P, Majmudar P, Trattler W, et al. Evaluation of a new artificial tear formulation for the management of tear film stability and visual function in patients with dry eye. Clin Ophthalmol. 2017;11:1883-9. doi: 10.2147/OPTH.S144369 pmid: 29089744

Arnold WK, Savage CR, Brissette CA, Seshu J, Livny J, Stevenson B. RNA-Seq of Borrelia burgdorferi in Multiple Phases of Growth Reveals Insights into the Dynamics of Gene Expression, Transcriptome Architecture, and Noncoding RNAs. PLoS One. 2016;11(10):e0164165. doi: 10.1371/journal.pone.0164165 pmid: 27706236

Sacchetti M, Lambiase A. Diagnosis and management of neurotrophic keratitis. Clin Ophthalmol. 2014;8:571-9. doi: 10.2147/OPTH.S45921 pmid: 24672223

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