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Effects of Artificial Tear Preparations With Three Different Ingredients on Contrast Sensitivity in Patients With Dry Eye Syndrome

Sezen Akkaya


To investigate the effects of artificial tear preparations (ATP) with three different ingredients on contrast sensitivity in patients with dry eye syndrome this study has been performed.

Contrast sensitivity measurements were obtained before and 5, 15, 30, 60 and 90 minutes after administering three different ATPs, containing dextran 70, hydroxypropyl methylcellulose (ATP-1), polyvinyl alcohol-povidone (ATP-2) and carbomer (ATP-3) to one eye of each of 20 patients with dry eye syndrome, who had been divided into three groups. Contrast sensitivity measurements were obtained at 1.5, 3, 6, 12 and 18 spatial frequencies (cpd).

Compared with the baseline measurements, ATP-1 provided significant increases at the 15th minute at 1.5 and 3 cpd; at the 60th minute at 12 cpd; and at the 30th minute at 18cpd. ATP-2 significantly increased contrast sensitivity compared with the baseline at the 15th, 30th, 60th and 90th min measurements recorded at 1.5, 3, 12, and 18 cpd. ATP-3 provided significant increases at 60th and 90th min measurements at 18 cpd compared with the baseline.

While the ATP-2 increased the majority of contrast sensitivity measurements both at early, mid and late terms, the ATP-1, and ATP-3 were found to be effective on mid-term and late-term contrast sensitivity measurements, respectively.

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