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Collagen Matrix Implantation Following Pterygium Excision: Outcomes of a Preliminary Tested Hypothesis

Muhammad Arish, Abdul-Nasser Nadjafi, Mojdeh Mojdeh Jahangard

Abstract


This study was conducted to evaluate the effect of collagen matrix implant on pterygium recurrence compared with a control group following pterygium removal surgery. Following informed consent, twenty eyes of 20 patients (females = 13, males = 7, aged 23–67 years) were randomly allocated into two equal groups. Pterygia of all patients were excised using the bare sclera technique; however, for patients in the intervention group a 1×2 mm collagen matrix graft (iGen™) was implanted subconjunctivally. Patients were followed up for recurrence and complications within six months. Results revealed that only two eyes in the control group and one eye in the intervention group developed recurrence (p=0.50); no dellen formation was observed. In conclusion, the use of biodegradable collagen matrix implants (iGen™) following pterygium excision seems to be associated with a lower risk of recurrence; however, the statistical difference between groups was not significant. Further studies with adequate sample size are recommended.

References


Ang LP, Chua JL, Tan DT. Current concepts and techniques in pterygium treatment. Curr Opin Ophthalmol. 2007 Jul;18(4):308-13. PMID: 17568207

Garg A, Nassaralla BA El-Toukhy E, Kaynak-Hekimhan P, Moreker S. Surgical and Medical Management of Pterygium, 1st Edition. India: Jaypee Brothers Medical Publishers; 2009.

Salman AG, Mansour DE. The recurrence of pterygium after different modalities of surgical treatment. Saudi J Ophthalmol. 2011 Oct;25(4):411-5. PMID: 23960956.

Cillino S, Di Pace F, Cillino G, Casuccio A. Biodegradable collagen matrix implant for trabeculectomy: a 24-month randomized clinical trial. Eye (Lond). 2011 Dec;25(12):1598-606. PMID: 21921953

Zelefsky JR, Hsu WC, and Ritch R. Biodegradable collagen matrix implant for trabeculectomy. Expert Review of Ophthalmology. 2008; 3(6): 613-617.

Young AL, Leung GY, Wong AK, Cheng LL, Lam DS. A randomised trial comparing 0.02% mitomycin C and limbal conjunctival autograft after excision of primary pterygium. Br J Ophthalmol. 2004 Aug;88(8):995-7. PubMed PMID: 15258011;.

Saw SM, Tan D. Pterygium: prevalence, demography and risk factors. Ophthalmic Epidemiol. 1999 Sep;6(3):219-28. PMID: 10487976

Moran DJ, Hollows FC. Pterygium and ultraviolet radiation: a positive correlation. Br J Ophthalmol. 1984 May;68(5):343-6. PMID: 6712914

Hill JC, Maske R. Pathogenesis of pterygium. Eye. 1989;3(2):218-26.

Sáenz-Madrazo N, Sarmiento B, Colás T, Julve A, Alonso M, Seoane R. Biodegradable Collagen Matrix Implant: New treatment for pterygium. Boston: VI World Cornea Congress; 2010.

Nilforushan N, Yadgari M, Ghasemi-Falavarjani K, Ehteshami-Afshar E. Evaluation of subconjunctival oculusgen implantation as an adjunct to trabeculectomy. Iranian Journal of Ophthalmology. 2010;22(2):55-62.


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