Bilateral Choroidal Detachment Induced by Unilateral Application of a Fixed Combination of Topical Timolol Maleate and Brinzolamide
Medical hypothesis discovery and innovation in ophthalmology,
Vol. 5 No. 4 (2016),
1 December 2016
AbstractWe describe a 66-year-old man who developed bilateral choroidal detachment that was induced by unilateral topical administration of a fixed combination of 1% brinzolamide and 0.5% timolol maleate the day after an uneventful phacoemulsification surgery and intraocular lens implantation involving his right eye. We believe that the reaction was an idiosyncratic reaction, most likely against brinzolamide. The condition improved rapidly after the cessation of the fixed combination of brinzolamide and timolol maleate and treatment with 1% topical prednisolone acetate every hour and 1% cyclopentolate twice a day bilaterally. Although there are several similar cases involving choroidal detachment after oral acetazolamide and topical dorzolamide treatment mentioned in the literature, the present case is the first case report involving bilateral choroidal detachment after topical treatment with brinzolamide.Â
Brubaker RF, Pederson JE. Ciliochoroidal detachment. Surv Ophthalmol. 1983 Mar-Apr;27(5):281-9. Review. PMID: 6407132.
Elagouz M, Stanescu-Segall D, Jackson TL. Uveal effusion syndrome. Surv Ophthalmol. 2010 Mar-Apr;55(2):134-45. Review. PMID: 20159229.
Parthasarathi S, Myint K, Singh G, Mon S, Sadasivam P, Dhillon B. Bilateral acetazolamide-induced choroidal effusion following cataract surgery. Eye (Lond). 2007 Jun;21(6):870-2. PMID: 17293785.
Mancino R, Varesi C, Cerulli A, Aiello F, Nucci C. Acute bilateral angle-closure glaucoma and choroidal effusion associated with acetazolamide administration after cataract surgery. J Cataract Refract Surg. 2011 Feb;37(2):415-7. PMID: 21241929.
Malagola R, Arrico L, Giannotti R, Pattavina L. Acetazolamide-induced cilio-choroidal effusion after cataract surgery: unusual posterior involvement. Drug Des Devel Ther. 2013;7:33-6. PMID: 23378740.
Davani S, Delbosc B, Royer B, Kantelip JP. Choroidal detachment induced by dorzolamide 20 years after cataract surgery. Br J Ophthalmol. 2002 Dec;86(12):1457-8. PMID: 12446402.
Goldberg S, Gallily R, Bishara S, Blumenthal EZ. Dorzolamide-induced choroidal detachment in a surgically untreated eye. Am J Ophthalmol. 2004 Aug;138(2):285-6. PMID: 15289139.
Doherty MD, Wride NK, Birch MK, Figueiredo FC. Choroidal detachment in association with topical dorzolamide: is hypotony always the cause? Clin Exp Ophthalmol. 2009 Sep;37(7):750-2. PMID: 19788679.
Silver LH. Clinical efficacy and safety of brinzolamide (Azopt), a new topical carbonic anhydrase inhibitor for primary open-angle glaucoma and ocular hypertension. Brinzolamide Primary Therapy Study Group. Am J Ophthalmol. 1998 Sep;126(3):400-8. PMID: 9744373.
Krieg PH, Schipper I. Drug-induced ciliary body oedema: a new theory. Eye (Lond). 1996;10 ( Pt 1):121-6. PMID: 8763317.
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