Consanguineous Marriage as a Risk Factor for Developing Keratoconus
Medical hypothesis discovery and innovation in ophthalmology,
Vol. 7 No. 1 (2018),
11 March 2018
,
Page 17-21
Abstract
Heredity plays an important role in keratoconus (KC). Consanguineous marriage (CM) can affect the transmission of recessively inherited conditions. We aimed to investigate the role of consanguineous marriage in the development of KC. This study included two groups: the first group comprised 415 patients who underwent surgery for KC for the first time at Khalili University Hospital (Shiraz, Iran), between 2010 and 2014; the second group comprised 415 healthy individuals who served as age- and sex-matched controls for the patient group. All study subjects were from the Fars province in Iran. CM type was evaluated by a standard checklist in both groups. The mean inbreeding coefficient (α) was evaluated and compared between the two groups. The percentage of parental first-cousin marriages was 35.4% in the patient group and 18.3% in the control group. The mean inbreeding coefficient (α) was 0.0291 in the patient group and 0.0135 in the control group. Patients with KC had a significantly higher mean inbreeding coefficient (α) than controls (T = 8, df = 828, P < 0.001). Our study suggests that CM can play a role in the pathogenesis of KC. As this disease is among the most frequent ocular disorders in our country, CM should be considered by health care systems within their screening programs.References
Ziaei H, Jafarinasab MR, Javadi MA, Karimian F, Poorsalman H, Mahdavi M, et al. Epidemiology of keratoconus in an Iranian population. Cornea. 2012;31(9):1044-7. doi: 10.1097/ICO.0b013e31823f8d3c pmid: 22710491
Khaled ML, Helwa I, Drewry M, Seremwe M, Estes A, Liu Y. Molecular and Histopathological Changes Associated with Keratoconus. Biomed Res Int. 2017;2017:7803029. doi: 10.1155/2017/7803029 pmid: 28251158
Gatzioufas Z, Panos GD, Hamada S. Keratoconus: is it a Non-inflammatory Disease? Med Hypothesis Discov Innov Ophthalmol. 2017;6(1):1-2. pmid: 28428967
Jadidi K, Nejat F, Mosavi SA, Naderi M, Katiraee A, Janani L, et al. Full-ring Intrastromal Corneal Implantation for Correcting High Myopia in Patients with Severe Keratoconus. Med Hypothesis Discov Innov Ophthalmol. 2016;5(3):89-95. pmid: 28293654
T AI, Elmor O. Intracorneal Rings (INTACS SK) Might be Beneficial in Keratoconus; A Prospective Nonrandomized Study. Med Hypothesis Discov Innov Ophthalmol. 2013;2(2):35-40. pmid: 24600640
Norouzpour A, Mehdizadeh A. A novel insight into keratoconus: mechanical fatigue of the cornea. Med Hypothesis Discov Innov Ophthalmol. 2012;1(1):14-7. pmid: 24600612
Akkaya S. Rate of Parental Consanguineous Marriage among Patients with Visual Impairments in Turkey. Med Hypothesis Discov Innov Ophthalmol. 2016;5(4):115-20. pmid: 28293658
Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28(4):293-322. pmid: 6230745
Stabuc-Silih M, Strazisar M, Ravnik-Glavac M, Hawlina M, Glavac D. Genetics and clinical characteristics of keratoconus. Acta Dermatovenerol Alp Pannonica Adriat. 2010;19(2):3-10. pmid: 20664914
Fournie P, Touboul D, Arne JL, Colin J, Malecaze F. [Keratoconus]. J Fr Ophtalmol. 2013;36(7):618-26. doi: 10.1016/j.jfo.2013.05.004 pmid: 23911067
Hughes AE, Dash DP, Jackson AJ, Frazer DG, Silvestri G. Familial keratoconus with cataract: linkage to the long arm of chromosome 15 and exclusion of candidate genes. Invest Ophthalmol Vis Sci. 2003;44(12):5063-6. pmid: 14638698
Rabinowitz YS. The genetics of keratoconus. Ophthalmol Clin North Am. 2003;16(4):607-20, vii. doi: 10.1016/s0896-1549(03)00099-3 pmid: 14741001
Kumaramanickavel G, Joseph B, Vidhya A, Arokiasamy T, Shridhara Shetty N. Consanguinity and ocular genetic diseases in South India: analysis of a five-year study. Community Genet. 2002;5(3):182-5. doi: 10.1159/000066334 pmid: 14960889
Bagheri M, Farvardin M, Saadat M. A study of consanguineous marriage as a risk factor for developing comitant strabismus. J Community Genet. 2015;6(2):177-80. doi: 10.1007/s12687-015-0213-9 pmid: 25644872
Gordon-Shaag A, Millodot M, Essa M, Garth J, Ghara M, Shneor E. Is consanguinity a risk factor for keratoconus? Optom Vis Sci. 2013;90(5):448-54. doi: 10.1097/OPX.0b013e31828da95c pmid: 23584486
Millodot M, Shneor E, Albou S, Atlani E, Gordon-Shaag A. Prevalence and associated factors of keratoconus in Jerusalem: a cross-sectional study. Ophthalmic Epidemiol. 2011;18(2):91-7. doi: 10.3109/09286586. 2011.560747 pmid: 21401417
Owens H, Gamble G. A profile of keratoconus in New Zealand. Cornea. 2003;22(2):122-5. pmid: 12605045
Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, et al. Baseline findings in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Invest Ophthalmol Vis Sci. 1998;39(13):2537-46. pmid: 9856763
Khan AO, Shinwari J, Abu Dhaim N, Khalil D, Al Sharif L, Al Tassan N. Potential linkage of different phenotypic forms of childhood strabismus to a recessive susceptibility locus (16p13.12-p12.3). Mol Vis. 2011;17:971-6. pmid: 21541264
Hamamy H. Consanguineous marriages : Preconception consultation in primary health care settings. J Community Genet. 2012;3(3):185-92. doi: 10.1007/s12687-011-0072-y pmid: 22109912
Akrami SM, Montazeri V, Shomali SR, Heshmat R, Larijani B. Is there a significant trend in prevalence of consanguineous marriage in Tehran? A review of three generations. J Genet Couns. 2009;18(1):82-6. doi: 10.1007/s10897-008-9191-y pmid: 18843527
Saadat M, Ansari-Lari M, Farhud DD. Consanguineous marriage in Iran. Ann Hum Biol. 2004;31(2):263-9. doi: 10.1080/03014460310001652211 pmid: 15204368
- Abstract Viewed: 1854 times
- Full Text PDF Downloaded: 1419 times