Glaucomatous Optic Neuropathy Management: the Role of Neuroprotective Agents
Medical hypothesis discovery and innovation in ophthalmology,
Vol. 2 No. 2 (2013),
1 June 2013
AbstractGlaucoma is a major cause of worldwide irreversible blindness. The central role of raised intraocular pressure (IOP) is being questioned as many patients continue to demonstrate a clinically downhill course despite initial control of IOP. The latest concept of recognizing glaucoma as a multifactorial, progressive, neurodegenerative disease of retinal ganglion cells (RGCSs) associated with characteristic axon degeneration in the optic nerve emphasizes that several pressure-independent mechanisms are responsible for the development and progression of glaucomatous optic neuropathy. Neuroprotection as a pharmacological strategy to mitigate retinal ganglion cell death has been a popular current approach. The aim of this review is to evaluate the neuroprotective potential of calcium channel blockers in glaucomatous optic neuropathy.
- Abstract Viewed: 2854 times
- Full Text PDF Downloaded: 5159 times